The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

DOI Web Site Web Site 被引用文献3件
  • Stefania Petrosino
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche Pozzuoli (NA) Italy
  • Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche Pozzuoli (NA) Italy

説明

<jats:sec><jats:label /><jats:p>Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this compound is naturally produced in many plant and animal food sources, as well as in cells and tissues of mammals, and endowed with important neuroprotective, anti‐inflammatory and analgesic actions. Several efforts have been made to identify the molecular mechanism of action of PEA and explain its multiple effects both in the central and the peripheral nervous system. Here, we provide an overview of the pharmacology, efficacy and safety of PEA in neurodegenerative disorders, pain perception and inflammatory diseases. The current knowledge of new formulations of PEA with smaller particle size (i.e. micronized and ultra‐micronized) when given alone or in combination with antioxidant flavonoids (i.e. luteolin) and stilbenes (i.e. polydatin) is also reviewed.</jats:p></jats:sec><jats:sec><jats:title>Linked Articles</jats:title><jats:p>This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc</jats:ext-link></jats:p></jats:sec>

収録刊行物

被引用文献 (3)*注記

もっと見る

問題の指摘

ページトップへ