Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

DOI Web Site 被引用文献14件

説明

<jats:p>The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 domains serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. The SH3 binding sites of two SH3 binding proteins were localized to a nine- or ten-amino acid stretch very rich in proline residues. Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor. Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets.</jats:p>

収録刊行物

  • Science

    Science 259 (5098), 1157-1161, 1993-02-19

    American Association for the Advancement of Science (AAAS)

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