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- Takaaki Teranishi
- Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
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- Tetsuro Murokawa
- Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
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- Masaru Enomoto
- Biomaterial Engineering Research Group, Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Japan
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- Shigefumi Kuwahara
- Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
説明
<jats:title>Abstract</jats:title> <jats:p>The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.</jats:p>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 79 (1), 11-15, 2015-01-02
Informa UK Limited
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360011145529555712
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- ISSN
- 13476947
- 09168451
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- データソース種別
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- Crossref