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- Mischo Kursar
- 1Max Planck Institute for Infection Biology, Department of Immunology
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- Kerstin Bonhagen
- 2Deutsches Rheumaforschungszentrum, Schumannstr. 21/22, 10117 Berlin, Germany
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- Joachim Fensterle
- 1Max Planck Institute for Infection Biology, Department of Immunology
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- Anne Köhler
- 1Max Planck Institute for Infection Biology, Department of Immunology
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- Robert Hurwitz
- 1Max Planck Institute for Infection Biology, Department of Immunology
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- Thomas Kamradt
- 2Deutsches Rheumaforschungszentrum, Schumannstr. 21/22, 10117 Berlin, Germany
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- Stefan H.E. Kaufmann
- 1Max Planck Institute for Infection Biology, Department of Immunology
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- Hans-Willi Mittrücker
- 1Max Planck Institute for Infection Biology, Department of Immunology
説明
<jats:p>CD4+ T cell help is important for the generation of CD8+ T cell responses. We used depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell responses after secondary infection of mice with the intracellular bacterium Listeria monocytogenes, or after boost immunization by specific peptide or DNA vaccination. Surprisingly, anti-CD4 mAb treatment during secondary CD8+ T cell responses markedly enlarged the population size of antigen-specific CD8+ T cells. After boost immunization with peptide or DNA, this effect was particularly profound, and antigen-specific CD8+ T cell populations were enlarged at least 10-fold. In terms of cytokine production and cytotoxicity, the enlarged CD8+ T cell population consisted of functional effector T cells. In depletion and transfer experiments, the suppressive function could be ascribed to CD4+CD25+ T cells. Our results demonstrate that CD4+ T cells control the CD8+ T cell response in two directions. Initially, they promote the generation of a CD8+ T cell responses and later they restrain the strength of the CD8+ T cell memory response. Down-modulation of CD8+ T cell responses during infection could prevent harmful consequences after eradication of the pathogen.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 196 (12), 1585-1592, 2002-12-09
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1360011145572207488
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- NII論文ID
- 30017416949
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- ISSN
- 15409538
- 00221007
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- データソース種別
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