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- Nicole Prior
- Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
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- Patricia Inacio
- Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
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- Meritxell Huch
- Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
書誌事項
- 公開日
- 2019-07-12
- DOI
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- 10.1136/gutjnl-2019-319256
- 公開者
- BMJ
この論文をさがす
説明
<jats:p>Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.</jats:p>
収録刊行物
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- Gut
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Gut 68 (12), 2228-2237, 2019-07-12
BMJ
