Developing and maintaining protective CD8<sup>+</sup> memory T cells
説明
<jats:p><jats:bold>Summary: </jats:bold> A critical aim of vaccine‐related research is to identify the mechanisms by which memory T cells are formed and maintained over long periods of time. In recent years, we have designed experiments aimed at addressing two key questions: (i) what are the factors that maintain functionally responsive CD8<jats:sup>+</jats:sup> memory cells over long periods of time, and (ii) what are the signals during the early stages of infection that drive the differentiation of long‐lived CD8<jats:sup>+</jats:sup> memory T cells? We have identified a role for CD4<jats:sup>+</jats:sup> T cells in the generation of CD8<jats:sup>+</jats:sup> T‐cell‐mediated protection from secondary challenge. While CD4<jats:sup>+</jats:sup> T cells appear to play a role in the programme of CD8 memory, we find that they are also required for the long‐term maintenance of CD8<jats:sup>+</jats:sup> memory T‐cell numbers and function. This property is independent of CD40–CD40L interactions, and we propose a role for CD4<jats:sup>+</jats:sup> T cells in maintaining the ability of CD8<jats:sup>+</jats:sup> memory T cells to respond to interleukin‐7 (IL‐7) and IL‐15. By manipulating both the time course of infection and the timing of antigen presentation to newly recruited CD8<jats:sup>+</jats:sup> T cells, we also demonstrate that the programming of effector and memory potential are at least partially distinct processes.</jats:p>
収録刊行物
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- Immunological Reviews
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Immunological Reviews 211 (1), 146-153, 2006-06
Wiley
