In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor
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- J E Cronan
- Department of Microbiology, University of Illinois, Urbana 61801, USA. John_Cronan@qms1.life.uiuc.edu
Abstract
<jats:p>In vitro experiments point to fatty acyl coenzymes A (acyl-CoAs) rather than unesterified fatty acids as the small-molecule ligands regulating DNA binding by the FadR protein of Escherichia coli. To provide an in vivo test of this specificity, unesterified fatty acids were generated within the cellular cytosol. These fatty acids were found to be efficient modulators of FadR action only when the acids could be converted to acyl-CoAs.</jats:p>
Journal
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- Journal of Bacteriology
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Journal of Bacteriology 179 (5), 1819-1823, 1997-03
American Society for Microbiology
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Details 詳細情報について
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- CRID
- 1360011145613107328
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- ISSN
- 10985530
- 00219193
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- Data Source
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- Crossref