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- Fernando López
- Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain
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- Juan P. Rodrigo
- Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain
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- Antonio Cardesa
- Department of Anatomic Pathology Hospital Clinic University of Barcelona Barcelona Spain
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- Asterios Triantafyllou
- Department of Oral Pathology School of Dentistry University of Liverpool Liverpool United Kingdom
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- Kenneth O. Devaney
- Department of Pathology Allegiance Health Jackson Michigan
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- William M. Mendenhall
- Department of Radiation Oncology University of Florida Gainesville Florida
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- Missak Haigentz
- Department of Medicine Division of Oncology Albert Einstein College of Medicine Montefiore Medical Center Bronx New York
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- Primož Strojan
- Department of Radiation Oncology Institute of Oncology Ljubljana Slovenia
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- Phillip K. Pellitteri
- Department of Otolaryngology–Head and Neck Surgery Guthrie Health System Sayre Pennsylvania
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- Carol R. Bradford
- Department of Otolaryngology–Head and Neck Surgery University of Michigan Ann Arbor Michigan
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- Ashok R. Shaha
- Head and Neck Service Memorial Sloan–Kettering Cancer Center New York New York
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- Jennifer L. Hunt
- Department of Pathology University of Arkansas for Medical Sciences Little Rock Arkansas
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- Remco de Bree
- Department of Otolaryngology–Head and Neck Surgery VU University Medical Center Amsterdam The Netherlands
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- Robert P. Takes
- Department of Otolaryngology–Head and Neck Surgery Radboud University Medical Center Nijmegen The Netherlands
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- Alessandra Rinaldo
- University of Udine School of Medicine Udine Italy
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- Alfio Ferlito
- University of Udine School of Medicine Udine Italy
抄録
<jats:title>Abstract</jats:title><jats:p>Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high‐risk features. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5‐year disease‐free survival [DFS] <20%) with high rates of locoregional recurrence and distant metastasis. The present review aims to summarize the current state of knowledge on the molecular biology, pathological diagnosis, and management of this disease. © 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck</jats:italic> 38: 147–155, 2016</jats:p>
収録刊行物
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- Head & Neck
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Head & Neck 38 (1), 147-155, 2015-05-22
Wiley