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- Ari Rosenberg
- Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
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- Jaclyn Sky Patterson
- Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
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- Dora E. Angelaki
- Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
抄録
<jats:title>Significance</jats:title> <jats:p>Autism is a pervasive disorder that broadly impacts perceptual, cognitive, social, and motor functioning. Across individuals, the disorder manifests with a large degree of phenotypic diversity. Here, we propose that autism symptomatology reflects alterations in neural computation. Using neural network simulations, we show that a reduction in the amount of inhibition occurring through a computation called divisive normalization can account for perceptual consequences reported in autism, as well as proposed changes in the extent to which past experience influences the interpretation of current sensory information in individuals with the disorder. A computational perspective can help bridge our understandings of the genetic/molecular basis of autism and its behavioral characteristics, providing insights into the disorder and possible courses of treatment.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 112 (30), 9158-9165, 2015-07-13
Proceedings of the National Academy of Sciences