Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis

DOI PDF 1 Citations
  • Sebastian Herich
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Tilman Schneider-Hohendorf
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Astrid Rohlmann
    Institute of Anatomy and Molecular Neurobiology University of Münster, Münster, Germany
  • Maryam Khaleghi Ghadiri
    Department of Neurosurgery, University Hospital Münster, Münster, Germany
  • Andreas Schulte-Mecklenbeck
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Lisa Zondler
    Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany
  • Claudia Janoschka
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Patrick Ostkamp
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Jannis Richter
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Johanna Breuer
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Stoyan Dimitrov
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
  • Hans-Georg Rammensee
    Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany
  • Oliver M Grauer
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Luisa Klotz
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Catharina C Gross
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Walter Stummer
    Department of Neurosurgery, University Hospital Münster, Münster, Germany
  • Markus Missler
    Institute of Anatomy and Molecular Neurobiology University of Münster, Münster, Germany
  • Alexander Zarbock
    Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany
  • Dietmar Vestweber
    Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, Germany
  • Heinz Wiendl
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany
  • Nicholas Schwab
    Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany

Description

<jats:p>Specific immune-cell populations patrol the CNS in search of pathogens and tumours. Herich et al. identify CD4+ CCR5high GzmK+ effector-memory cells as a brain-surveilling subpopulation capable of crossing the uninflamed blood-brain barrier, and reveal alterations in this population in HIV+ patients with neurological symptoms and in patients with multiple sclerosis.</jats:p>

Journal

  • Brain

    Brain 142 (11), 3411-3427, 2019-09-28

    Oxford University Press (OUP)

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