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- Joseph A. Garcia
- Department of Biochemistry,
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- Di Zhang
- Department of Biochemistry,
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- Sandi Jo Estill
- Department of Biochemistry,
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- Carolyn Michnoff
- Department of Biochemistry,
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- Jared Rutter
- Department of Biochemistry,
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- Martin Reick
- Department of Biochemistry,
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- Kristin Scott
- Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
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- Ramon Diaz-Arrastia
- Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
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- Steven L. McKnight
- Department of Biochemistry,
説明
<jats:p>Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a β-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory.</jats:p>
収録刊行物
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- Science
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Science 288 (5474), 2226-2230, 2000-06-23
American Association for the Advancement of Science (AAAS)