Ubiquitylation of Ion Channels

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<jats:p>Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.</jats:p>

収録刊行物

  • Physiology

    Physiology 20 (6), 398-407, 2005-12

    American Physiological Society

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