Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

  • Yongmei Xu
    Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Sayaka Masuko
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  • Majde Takieddin
    Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.
  • Haoming Xu
    Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Renpeng Liu
    Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Juliana Jing
    Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Shaker A. Mousa
    Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.
  • Robert J. Linhardt
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  • Jian Liu
    Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

書誌事項

公開日
2011-10-28
DOI
  • 10.1126/science.1207478
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>An enzymatic synthesis may ultimately offer a more efficient means of producing an important class of anticoagulant drugs.</jats:p>

収録刊行物

  • Science

    Science 334 (6055), 498-501, 2011-10-28

    American Association for the Advancement of Science (AAAS)

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