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- Shabir A. Lone
- Clinical Microbiology and Infectious Diseases Faculty of Health Sciences School of Pathology University of the Witwatersrand Johannesburg South Africa
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- Aijaz Ahmad
- Clinical Microbiology and Infectious Diseases Faculty of Health Sciences School of Pathology University of the Witwatersrand Johannesburg South Africa
説明
<jats:title>summary</jats:title><jats:p>A paradigm shift of candidiasis from <jats:italic>Candida albicans</jats:italic> to non‐albicans <jats:italic>Candida</jats:italic> species has fundamentally increased with the advent of <jats:italic>C. auris</jats:italic>. <jats:italic>C. auris,</jats:italic> despite being a newly emerged multidrug‐resistant fungal pathogen, is associated with severe invasive infections and outbreaks with high mortality rates. Initially reported from Japan in 2009, <jats:italic>C. auris</jats:italic> have now been found in different countries on all the continents except Antarctica. Due to its capability of nosocomial transmission and forming adherent biofilms on clinically important substrates, a high number of related hospital outbreaks have been reported worldwide. As <jats:italic>C. auris</jats:italic> is a multidrug‐resistant pathogen and is prone to misidentification by available conventional methods, it becomes difficult to detect and manage <jats:italic>C. auris</jats:italic> infection and also limits the therapeutic options against this deadly pathogen. The emergence of multidrug‐resistant <jats:italic>C. auris</jats:italic> advocates and amplifies the vigilance of early diagnosis and appropriate treatment of fungal infections. In this review, we discussed the nine‐year‐old history of <jats:italic>C. auris</jats:italic>—its trends in global emergence, epidemiological relatedness, isolation, mortality, associated risk factors, virulence factors, drug resistance and susceptibility testing, diagnostic challenges, microbiological characteristics, therapeutic options and infection prevention and control associated with this pathogen.</jats:p>
収録刊行物
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- Mycoses
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Mycoses 62 (8), 620-637, 2019-06-18
Wiley