Potent Free Radical Scavenging Activity of Propol Isolated from Brazilian Propolis
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- Purusotam Basnet
- Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany
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- Tetsuya Matsuno
- Institute of Cancer Research, Columbia University, 701 West 168th Street, New York, NY 10032, USA
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- Richard Neidlein
- Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany
説明
<jats:title>Abstract</jats:title> <jats:p> We evaluated free radical scavenging activity of the water, methanol and chloroform extracts of propolis in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and xanthine-xanthine oxidase (XOD) generated superoxide anion assay systems. The free radical scavenging activity guided fractionation and chemical analysis led to the isolation of a new compound, propol {3-[4-hydroxy-3-(3-oxo-but-1-enyl)-phenyl]-acrylic acid) from the water extract, which was more potent than most common antioxidants such as vitamin C and vitamin E (α-tocopherol) in these assay systems.</jats:p>
収録刊行物
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- Zeitschrift für Naturforschung C
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Zeitschrift für Naturforschung C 52 (11-12), 828-833, 1997-12-01
Walter de Gruyter GmbH