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- David K. Welsh
- Department of Psychiatry, University of California, San Diego, La Jolla, California 92093;
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- Joseph S. Takahashi
- Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390
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- Steve A. Kay
- Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093
説明
<jats:p> The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity depends on sufficient membrane depolarization and levels of intracellular calcium and cAMP. In the intact SCN, cellular oscillations are synchronized and reinforced by rhythmic synaptic input from other cells, resulting in a reproducible topographic pattern of distinct phases and amplitudes specified by SCN circuit organization. The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision. Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN. </jats:p>
収録刊行物
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- Annual Review of Physiology
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Annual Review of Physiology 72 (1), 551-577, 2010-03-17
Annual Reviews
