Spatio‐Temporal Control of LbL Films for Biomedical Applications: From 2D to 3D

DOI Web Site Web Site 被引用文献2件
  • Claire Monge
    CNRS, UMR 5628, LMGP 3 parvis Louis Néel F‐38016 Grenoble France
  • Jorge Almodóvar
    University of Puerto‐Mayagüez Department of Chemical Engineering PO Box 9000 PR 00681–9000 Puerto Rico
  • Thomas Boudou
    CNRS, UMR 5628, LMGP 3 parvis Louis Néel F‐38016 Grenoble France
  • Catherine Picart
    CNRS, UMR 5628, LMGP 3 parvis Louis Néel F‐38016 Grenoble France

書誌事項

公開日
2015-01-27
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/adhm.201400715
公開者
Wiley

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説明

<jats:p>Introduced in the '90s by Prof. Moehwald, Lvov, and Decher, the layer‐by‐layer (LbL) assembly of polyelectrolytes has become a popular technique to engineer various types of objects such as films, capsules and free standing membranes, with an unprecedented control at the nanometer and micrometer scales. The LbL technique allows to engineer biofunctional surface coatings, which may be dedicated to biomedical applications in vivo but also to fundamental studies and diagnosis in vitro. Initially mostly developed as 2D coatings and hollow capsules, the range of complex objects created by the LbL technique has greatly expanded in the past 10 years. In this Review, the aim is to highlight the recent progress in the field of LbL films for biomedical applications and to discuss the various ways to spatially and temporally control the biochemical and mechanical properties of multilayers. In particular, three major developments of LbL films are discussed: 1) the new methods and templates to engineer LbL films and control cellular processes from adhesion to differentiation, 2) the major ways to achieve temporal control by chemical, biological and physical triggers and, 3) the combinations of LbL technique, cells and scaffolds for repairing 3D tissues, including cardio‐vascular devices, bone implants and neuro‐prosthetic devices.</jats:p>

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