Nonstructural C Protein Is Required for Efficient Measles Virus Replication in Human Peripheral Blood Cells

DOI Web Site 被引用文献2件
  • Carine Escoffier
    <!--label omitted: 1-->Immunité et Infections Virales, IVMC, CNRS-UCBL, UMR 5537, 69372 Lyon Cedex 08, France1;
  • Serge Manié
    <!--label omitted: 1-->Immunité et Infections Virales, IVMC, CNRS-UCBL, UMR 5537, 69372 Lyon Cedex 08, France1;
  • Séverine Vincent
    <!--label omitted: 1-->Immunité et Infections Virales, IVMC, CNRS-UCBL, UMR 5537, 69372 Lyon Cedex 08, France1;
  • Claude P. Muller
    <!--label omitted: 2-->Laboratoire National de Santé, Département d’Immunologie, L-1011 Luxembourg BP1102, Luxembourg2; and
  • Martin Billeter
    <!--label omitted: 3-->Institut für Molekularbiologie, Universität Zürich, CH-8093 Zürich, Switzerland3
  • Denis Gerlier
    <!--label omitted: 1-->Immunité et Infections Virales, IVMC, CNRS-UCBL, UMR 5537, 69372 Lyon Cedex 08, France1;

書誌事項

公開日
1999-02
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.73.2.1695-1698.1999
公開者
American Society for Microbiology

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説明

<jats:title>ABSTRACT</jats:title><jats:p>The P gene of measles virus (MV) encodes the phosphoprotein, a component of the virus ribonucleoprotein complex, and two nonstructural proteins, C and V, with unknown functions. Growth of recombinant MV, defective in C or V expression, was explored in human peripheral blood mononuclear cells (PBMC). The production of infectious recombinant MV V<jats:sup>−</jats:sup>was comparable to that of parental MV tag in simian Vero fibroblasts and in PBMC. In contrast, MV C<jats:sup>−</jats:sup>progeny was strongly reduced in PBMC but not in Vero cells. Consistently, the expression of both hemagglutinin and fusion proteins, as well as that of nucleoprotein mRNA, was lower in MV C<jats:sup>−</jats:sup>-infected PBMC. Thus, efficient replication of MV in natural host cells requires the expression of the nonstructural C protein. The immunosuppression that accompanies MV infection is associated with a decrease in the in vitro lymphoproliferative response to mitogens. MV C<jats:sup>−</jats:sup>was as potent as MV tag or MV V<jats:sup>−</jats:sup>in inhibiting the phytohemagglutinin-induced proliferation of PBMC, indicating that neither the C protein nor the V protein is directly involved in this effect.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 73 (2), 1695-1698, 1999-02

    American Society for Microbiology

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