The leech excitatory peptide, a member of the GGNG peptide family: isolation and comparison with the earthworm GGNG peptides
抄録
<jats:p>A member of the GGNG peptide family was isolated from <jats:italic>Hirudo</jats:italic> <jats:italic>nipponia</jats:italic> (leech). GGNG peptides had only been isolated previously from earthworms. The C‐terminus structure of the leech peptide, LEP (leech excitatory peptide), was –Gly–Gly–Asn–amide, while that of the earthworm peptides, EEP (earthworm excitatory peptide), was –Gly–Gly–Asn–Gly. LEP exerted 1000‐fold more potent activities on leech gut than did EEP‐2. On the other hand, EEP‐2 was 1000‐fold more potent than LEP on the crop‐gizzard of the earthworm. Analog peptides of LEP and EEP‐2 were synthesized, and the myoactive potency of each analog on the leech and earthworm tissues was compared.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 410 (2-3), 437-442, 1997-06-30
Wiley