Ca2+-Antagonistic action of bevantolol on hypothalamic neurons in vitro: its comparison with those of other β-adrenoceptor antagonists, a local anesthetic and a Ca2+-antagonist
書誌事項
- 公開日
- 1996-01
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1016/0006-8993(95)01052-1
- 公開者
- Elsevier BV
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説明
The Ca(2+)-antagonistic action of bevantolol, a beta 1-adrenoceptor antagonist, on high- and low-voltage activated Ca2+ currents (HVA- and LVA-ICa) was examined on neurons dissociated from rat brain. Bevantolol (10(-6) to 10(-4) M) inhibited concentration-dependently both ICa. The IC50 value of bevantolol for LVA-ICa was 4 x 10(-5) M, while bevantolol at 10(-4) M inhibited HVA-ICa by 28.5 +/- 7.7%. The potency of bevantolol in inhibiting both ICa was greater than those of propranolol, labetalol and lidocaine, while the inhibitory action of bevantolol on voltage-activated Na+ current was weakest among them. Bevantolol may possess Ca(2+)-antagonistic action that is independent from local anesthetic action.
収録刊行物
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- Brain Research
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Brain Research 706 (2), 289-292, 1996-01
Elsevier BV