Gene duplication can impart fragility, not robustness, in the yeast protein interaction network
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- Guillaume Diss
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Isabelle Gagnon-Arsenault
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Anne-Marie Dion-Coté
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Hélène Vignaud
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Diana I. Ascencio
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Caroline M. Berger
- Département de Biologie, Université Laval, Québec, QC, Canada.
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- Christian R. Landry
- Département de Biologie, Université Laval, Québec, QC, Canada.
書誌事項
- 公開日
- 2017-02-10
- 権利情報
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- http://www.sciencemag.org/about/science-licenses-journal-article-reuse
- DOI
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- 10.1126/science.aai7685
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Robustness of protein networks</jats:title> <jats:p> It is thought that gene duplication helps cells maintain genetic robustness, but this seems not to be the whole story. Diss <jats:italic>et al.</jats:italic> investigated the fate of protein-protein interactions among duplicated genes in yeast. Some interacting duplicates evolved mutual dependence, resulting in a more fragile system. This finding helps us understand the evolutionary trajectories of gene duplications and how seemingly redundant genes can increase the complexity of protein interaction networks. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6325" page="630" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aai7685">630</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 355 (6325), 630-634, 2017-02-10
American Association for the Advancement of Science (AAAS)