Atrophic Gastritis and Intestinal Metaplasia in Japan: Results of a Large Multicenter Study
この論文をさがす
説明
<jats:sec><jats:title>ABSTRACT</jats:title></jats:sec><jats:sec><jats:title>Background.</jats:title><jats:p>This study evaluated the relationship between <jats:italic>Helicobacter pylori</jats:italic> infection, atrophic gastritis and intestinal metaplasia in Japan.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods.</jats:title><jats:p>This was a multicenter study performed in 21 centers in Japan. A total of 2455 individuals were enrolled. <jats:italic>H. pylori</jats:italic> status was determined by validated ELISAs. Atrophic gastritis was diagnosed by histology, endoscopy with Congo Red dye scattering or the Kimura‐Takemoto endoscopic classification.</jats:p></jats:sec><jats:sec><jats:title>Results.</jats:title><jats:p>Atrophic gastritis increased from 9.4% in those less than 20 years of age to > 70% in those aged 60 or older and was strongly associated with <jats:italic>H. pylori</jats:italic> infection. The overall prevalence of atrophic gastritis in <jats:italic>H. pylori</jats:italic> infection was 82.9% (1272/1534) compared with 9.8% (90/921) among uninfected (OR = 44.8; 95% CI = 34.7–57.8). Intestinal metaplasia was present in 43.1% (542/1258) of <jats:italic>H. pylori</jats:italic> positive persons compared with 6.2% (51/823) among the uninfected (OR = 11.5; 95% CI = 8.5–15.5). Atrophic gastritis in <jats:italic>H. pylori</jats:italic> positive Japanese was very high in the younger generation (38.5% in those aged 20 or less and 58.5% in those 21–30).</jats:p></jats:sec><jats:sec><jats:title>Conclusions.</jats:title><jats:p>Atrophic gastritis and intestinal metaplasia were strongly associated with <jats:italic>H. pylori</jats:italic> and not with aging. The fall in prevalence of <jats:italic>H. pylori</jats:italic> in Japan has not been associated with a corresponding fall in the prevalence of atrophic gastritis among those with <jats:italic>H. pylori</jats:italic> infection. The high prevalence of the precursor lesion, atrophic gastritis with intestinal metaplasia, among those with <jats:italic>H. pylori</jats:italic> infection suggests that the risk of development of early gastric cancer will continue to remain high in Japan.</jats:p></jats:sec>
収録刊行物
-
- Helicobacter
-
Helicobacter 6 (4), 294-299, 2001-12
Wiley