Chemical Synthesis of 23 kDa Glycoprotein by Repetitive Segment Condensation: A Synthesis of MUC2 Basal Motif Carrying Multiple O-GalNAc Moieties
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- Hironobu Hojo
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Yoshiyuki Matsumoto
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Yuko Nakahara
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Emi Ito
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Yusuke Suzuki
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Minoru Suzuki
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Akemi Suzuki
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
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- Yoshiaki Nakahara
- Contribution from the Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan, and Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako 351-0198, Japan
書誌事項
- 公開日
- 2005-09-08
- DOI
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- 10.1021/ja053711b
- 公開者
- American Chemical Society (ACS)
この論文をさがす
説明
Peptide thioester corresponding to a MUC2 tandem repeat unit, which retains seven GalNAc moieties, was prepared by the Fmoc method followed by the low TfOH treatment to remove benzyl groups at the carbohydrate portions. The glycosylated peptide thioester was then consecutively joined by the activation of a thioester group by silver ions to obtain a MUC2 tandem repeat model composed of 141 amino acids with 42 GalNAc moieties.
収録刊行物
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- Journal of the American Chemical Society
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Journal of the American Chemical Society 127 (39), 13720-13725, 2005-09-08
American Chemical Society (ACS)