Multivascular networks and functional intravascular topologies within biocompatible hydrogels
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- Bagrat Grigoryan
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Samantha J. Paulsen
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Daniel C. Corbett
- Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
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- Daniel W. Sazer
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Chelsea L. Fortin
- Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
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- Alexander J. Zaita
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Paul T. Greenfield
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Nicholas J. Calafat
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- John P. Gounley
- Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
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- Anderson H. Ta
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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- Fredrik Johansson
- Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
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- Amanda Randles
- Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
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- Jessica E. Rosenkrantz
- Nervous System, Somerville, MA 02143, USA.
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- Jesse D. Louis-Rosenberg
- Nervous System, Somerville, MA 02143, USA.
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- Peter A. Galie
- Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.
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- Kelly R. Stevens
- Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
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- Jordan S. Miller
- Department of Bioengineering, Rice University, Houston, TX 77005, USA.
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説明
<jats:title>Routes to independent vessel networks</jats:title> <jats:p> In air-breathing vertebrates, the circulatory and pulmonary systems contain separate networks of channels that intertwine but do not intersect with each other. Recreating such structures within cell-compatible materials has been a major challenge; even a single vasculature system can be a burden to create. Grigoryan <jats:italic>et al.</jats:italic> show that natural and synthetic food dyes can be used as photoabsorbers that enable stereolithographic production of hydrogels containing intricate and functional vascular architectures. Using this approach, they demonstrate functional vascular topologies for studies of fluid mixers, valves, intervascular transport, nutrient delivery, and host engraftment. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6439" page="458" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aav9750">458</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 364 (6439), 458-464, 2019-05-03
American Association for the Advancement of Science (AAAS)
