Synthetically engineered <i>Medea</i> gene drive system in the worldwide crop pest <i>Drosophila suzukii</i>
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- Anna Buchman
- Department of Entomology, University of California, Riverside, CA 92521;
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- John M. Marshall
- Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720;
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- Dennis Ostrovski
- Department of Entomology, University of California, Riverside, CA 92521;
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- Ting Yang
- Department of Entomology, University of California, Riverside, CA 92521;
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- Omar S. Akbari
- Department of Entomology, University of California, Riverside, CA 92521;
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説明
<jats:title>Significance</jats:title> <jats:p> Here we describe a fully functional gene drive system constructed in a major worldwide crop pest, <jats:italic>Drosophila suzukii</jats:italic> . This system is composed of a synthetic <jats:italic>Medea</jats:italic> drive with a maternal miRNA “toxin” and a zygotic “antidote,” and we demonstrate that it can bias inheritance with 100% efficiency and can persist in a population given high release frequencies. We discuss how such a system may be used to suppress <jats:italic>D. suzukii</jats:italic> populations or render them harmless to target crops. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 115 (18), 4725-4730, 2018-04-17
Proceedings of the National Academy of Sciences
