Glucose Fluctuation and Severe Internal Carotid Artery Siphon Stenosis in Type 2 Diabetes Patients
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- Futoshi Eto
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Kazuo Washida
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Masaki Matsubara
- Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Hisashi Makino
- Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Akio Takahashi
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Kotaro Noda
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Yorito Hattori
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Yuriko Nakaoku
- Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Kunihiro Nishimura
- Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Kiminori Hosoda
- Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
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- Masafumi Ihara
- Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan
説明
<jats:p>The impact of glucose fluctuation on intracranial artery stenosis remains to be elucidated. This study aimed to investigate the association between glucose fluctuation and intracranial artery stenosis. This was a cross-sectional study of type 2 diabetes mellitus (T2DM) patients equipped with the FreeStyle Libre Pro continuous glucose monitoring system (Abbott Laboratories) between February 2019 and June 2020. Glucose fluctuation was evaluated according to the standard deviation (SD) of blood glucose, coefficient of variation (%CV), and mean amplitude of glycemic excursions (MAGE). Magnetic resonance angiography was used to evaluate the degree of intracranial artery stenosis. Of the 103 patients, 8 patients developed severe internal carotid artery (ICA) siphon stenosis (≥70%). SD, %CV, and MAGE were significantly higher in the severe stenosis group than in the non-severe stenosis group (<70%), whereas there was no significant intergroup difference in the mean blood glucose and HbA1c. Multivariable logistic regression analysis adjusted for sex showed that SD, %CV, and MAGE were independent factors associated with severe ICA siphon stenosis. In conclusion, glucose fluctuation is significantly associated with severe ICA siphon stenosis in T2DM patients. Thus, glucose fluctuation can be a target of preventive therapies for intracranial artery stenosis and ischemic stroke.</jats:p>
収録刊行物
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- Nutrients
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Nutrients 13 (7), 2379-, 2021-07-12
MDPI AG
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キーワード
- Blood Glucose
- Male
- Blood Glucose Self-Monitoring
- mean amplitude of glycemic excursions
- glucose fluctuation
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
- Risk Factors
- Humans
- continuous glucose monitoring
- Carotid Stenosis
- Female
- Intracranial Arterial Diseases
- intracranial artery stenosis
- standard deviation
- Carotid Artery, Internal
- Magnetic Resonance Angiography
- Aged
- Retrospective Studies
詳細情報 詳細情報について
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- CRID
- 1360013168820601856
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- ISSN
- 20726643
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- PubMed
- 34371890
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
