Intramolecular Addition of a Dimethylamino C(sp3)–H Bond across C–C Triple Bonds Using IrCl(DTBM-SEGPHOS)(ethylene) Catalyst: Synthesis of Indoles from 2-Alkynyl-N-methylanilines
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<jats:title>Abstract</jats:title><jats:p>Intramolecular addition of a C(sp3)–H bond of the dimethylamino group across the C–C triple bond in 2-alkynyl-N,N-dimethylanilines is effectively catalyzed by a new iridium complex, IrCl(DTBM-SEGPHOS)(C2H4), in mesitylene at 150 °C. The intramolecular C(sp3)–H addition is followed by double-bond isomerization to afford 3-substituted indoles in good to high yields.</jats:p>
収録刊行物
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- Synthesis
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Synthesis 53 (17), 3057-3064, 2021-05-18
Georg Thieme Verlag KG
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詳細情報 詳細情報について
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- CRID
- 1360013168870038400
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- ISSN
- 1437210X
- 00397881
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- データソース種別
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- Crossref
- KAKEN