Metabolomics window into diabetic complications

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  • Tao Wu
    Center of Chinese Medical Therapy and Systems Biology Shanghai University of Traditional Chinese Medicine Shanghai China
  • Shuxuan Qiao
    School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China
  • Chenze Shi
    School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China
  • Shuya Wang
    School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China
  • Guang Ji
    Institute of Digestive Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China

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<jats:title>Abstract</jats:title><jats:p>Diabetes has become a major global health problem. The elucidation of characteristic metabolic alterations during the diabetic progression is critical for better understanding its pathogenesis, and identifying potential biomarkers and drug targets. Metabolomics is a promising tool to reveal the metabolic changes and the underlying mechanism involved in the pathogenesis of diabetic complications. The present review provides an update on the application of metabolomics in diabetic complications, including diabetic coronary artery disease, diabetic nephropathy, diabetic retinopathy and diabetic neuropathy, and this review provides notes on the prevention and prediction of diabetic complications.</jats:p>

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