Developmental cell programs are co-opted in inflammatory skin disease

DOI Web Site Web Site 被引用文献3件
  • Gary Reynolds
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Peter Vegh
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • James Fletcher
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Elizabeth F. M. Poyner
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Emily Stephenson
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Issac Goh
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Rachel A. Botting
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Ni Huang
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Bayanne Olabi
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Anna Dubois
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • David Dixon
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Kile Green
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Daniel Maunder
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Justin Engelbert
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Mirjana Efremova
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Krzysztof Polański
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Laura Jardine
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Claire Jones
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Thomas Ness
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Dave Horsfall
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Jim McGrath
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Christopher Carey
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Dorin-Mirel Popescu
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Simone Webb
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Xiao-nong Wang
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Ben Sayer
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Jong-Eun Park
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Victor A. Negri
    Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK.
  • Daria Belokhvostova
    Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK.
  • Magnus D. Lynch
    Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK.
  • David McDonald
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Andrew Filby
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Tzachi Hagai
    Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
  • Kerstin B. Meyer
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Akhtar Husain
    Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  • Jonathan Coxhead
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Roser Vento-Tormo
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Sam Behjati
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Steven Lisgo
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Alexandra-Chloé Villani
    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Jaume Bacardit
    School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, UK.
  • Philip H. Jones
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Edel A. O’Toole
    Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
  • Graham S. Ogg
    MRC Human Immunology Unit, Oxford Biomedical Research Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Neil Rajan
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Nick J. Reynolds
    Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
  • Sarah A. Teichmann
    Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Fiona M. Watt
    Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK.
  • Muzlifah Haniffa
    Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

抄録

<jats:title>Cellular beauty is skin deep</jats:title> <jats:p> Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds <jats:italic>et al.</jats:italic> used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba6500">eaba6500</jats:related-article> </jats:p>

収録刊行物

  • Science

    Science 371 (6527), eaba6500-, 2021-01-22

    American Association for the Advancement of Science (AAAS)

被引用文献 (3)*注記

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