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- Charles Fauvel
- Rouen University Hospital, FHU REMOD-VHF , F-76000 Rouen, France
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- Orianne Weizman
- Centre Hospitalier Régional Universitaire de Nancy , 54511 Vandoeuvre-Les-Nancy, France
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- Antonin Trimaille
- Nouvel Hôpital Civil, Centre Hospitalier Régional Universitaire de Strasbourg , 67000 Strasbourg, France
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- Delphine Mika
- Université Paris-Saclay, Inserm , UMR-S 1180, 92296 Chatenay-Malabry, France
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- Thibaut Pommier
- Centre hospitalier Universitaire de Dijon, 21000 Dijon, France
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- Nathalie Pace
- Centre Hospitalier Régional Universitaire de Nancy , 54511 Vandoeuvre-Les-Nancy, France
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- Amine Douair
- Centre Hospitalier Annecy Genevois , 74370 Epagny Metz-Tessy, France
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- Eva Barbin
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Antoine Fraix
- Centre Hospitalier Régional Universitaire de Nancy , 54511 Vandoeuvre-Les-Nancy, France
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- Océane Bouchot
- Centre Hospitalier Annecy Genevois , 74370 Epagny Metz-Tessy, France
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- Othmane Benmansour
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Guillaume Godeau
- Institut Cardiovasculaire Paris Sud , 91300 Massy, France
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- Yasmine Mecheri
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Romane Lebourdon
- Centre Hospitalier Universitaire de Bordeaux , 33076 Bordeaux, France
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- Cédric Yvorel
- Centre Hospitalier Universitaire de Saint-Etienne , 42270 Saint-Priest-en-Jarez, France
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- Michael Massin
- Centre Hospitalier Régional Universitaire de Nancy , 54511 Vandoeuvre-Les-Nancy, France
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- Tiphaine Leblon
- Centre Hospitalier Universitaire de Lille, Université Catholique de Lille , 59000 Lille, France
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- Chaima Chabbi
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Erwan Cugney
- Centre Hospitalier Régional Universitaire de Nancy , 54511 Vandoeuvre-Les-Nancy, France
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- Léa Benabou
- Centre Hospitalier Universitaire de Bordeaux , 33076 Bordeaux, France
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- Matthieu Aubry
- Hospices Civils de Lyon, Centre Hospitalier Universitaire , 69003 Lyon, France
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- Camille Chan
- Centre Hospitalier Universitaire de Bordeaux , 33076 Bordeaux, France
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- Ines Boufoula
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Clement Barnaud
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Léa Bothorel
- Centre Hospitalier Régionnal de Orléans , 45100 Orléans, France
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- Baptiste Duceau
- Université de Paris, PARCC, INSERM , 75015 Paris, France
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- Willy Sutter
- Université de Paris, PARCC, INSERM , 75015 Paris, France
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- Victor Waldmann
- Université de Paris, PARCC, INSERM , 75015 Paris, France
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- Guillaume Bonnet
- Université de Paris, PARCC, INSERM , 75015 Paris, France
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- Ariel Cohen
- Saint Antoine Hospital , 75012 Paris, France
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- Théo Pezel
- Lariboisiere hospital, APHP, University of Paris , 75010 Paris, France
抄録
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Aims</jats:title> <jats:p>While pulmonary embolism (PE) appears to be a major issue in COVID-19, data remain sparse. We aimed to describe the risk factors and baseline characteristics of patients with PE in a cohort of COVID-19 patients.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and results</jats:title> <jats:p>In a retrospective multicentre observational study, we included consecutive patients hospitalized for COVID-19. Patients without computed tomography pulmonary angiography (CTPA)-proven PE diagnosis and those who were directly admitted to an intensive care unit (ICU) were excluded. Among 1240 patients (58.1% men, mean age 64 ± 17 years), 103 (8.3%) patients had PE confirmed by CTPA. The ICU transfer and mechanical ventilation were significantly higher in the PE group (for both P < 0.001). In an univariable analysis, traditional venous thrombo-embolic risk factors were not associated with PE (P > 0.05), while patients under therapeutic dose anticoagulation before hospitalization or prophylactic dose anticoagulation introduced during hospitalization had lower PE occurrence [odds ratio (OR) 0.40, 95% confidence interval (CI) 0.14–0.91, P = 0.04; and OR 0.11, 95% CI 0.06–0.18, P < 0.001, respectively]. In a multivariable analysis, the following variables, also statistically significant in univariable analysis, were associated with PE: male gender (OR 1.03, 95% CI 1.003–1.069, P = 0.04), anticoagulation with a prophylactic dose (OR 0.83, 95% CI 0.79–0.85, P < 0.001) or a therapeutic dose (OR 0.87, 95% CI 0.82–0.92, P < 0.001), C-reactive protein (OR 1.03, 95% CI 1.01–1.04, P = 0.001), and time from symptom onset to hospitalization (OR 1.02, 95% CI 1.006–1.038, P = 0.002).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>PE risk factors in the COVID-19 context do not include traditional thrombo-embolic risk factors but rather independent clinical and biological findings at admission, including a major contribution to inflammation.</jats:p> </jats:sec>
収録刊行物
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- European Heart Journal
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European Heart Journal 41 (32), 3058-3068, 2020-07-13
Oxford University Press (OUP)