Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity
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- Zoltan Bozsoki
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Kira Gysel
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Simon B. Hansen
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Damiano Lironi
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Christina Krönauer
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Feng Feng
- Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
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- Noor de Jong
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Maria Vinther
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Manoj Kamble
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Mikkel B. Thygesen
- Department of Chemistry, University of Copenhagen, 1871 Frederiksberg, Denmark.
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- Ebbe Engholm
- Department of Chemistry, University of Copenhagen, 1871 Frederiksberg, Denmark.
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- Christian Kofoed
- Department of Chemistry, University of Copenhagen, 1871 Frederiksberg, Denmark.
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- Sébastien Fort
- Université Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.
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- John T. Sullivan
- Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.
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- Clive W. Ronson
- Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.
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- Knud J. Jensen
- Department of Chemistry, University of Copenhagen, 1871 Frederiksberg, Denmark.
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- Mickaël Blaise
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Giles Oldroyd
- Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
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- Jens Stougaard
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Kasper R. Andersen
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
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- Simona Radutoiu
- Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
抄録
<jats:title>Switching perception of friend and foe</jats:title> <jats:p> Lysine motif receptors in plants perceive glycans that signal the presence of pathogenic or symbiotic nitrogen-fixing microbes. Bozsoki <jats:italic>et al.</jats:italic> now define the portions of these receptors that create the discriminatory binding pocket (see the Perspective by Bisseling and Geurts). The motifs were conserved in receptors that initiate immune responses, reflecting the invariable nature of the chitin fragments that they sense. Conversely, the motifs in receptors that respond to symbiotic signals were more varied, reflecting the greater diversity of the lipochitooligosaccharides (Nod factors) that they sense. With domain swapping, the authors switched the Nod factor specificity of receptors from two legume species and also enabled a chitin receptor that was otherwise dedicated to the detection of pathogenic microbes to instead recognize Nod factors. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6504" page="663" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abb3377">663</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6504" page="620" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abd3857">620</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 369 (6504), 663-670, 2020-08-07
American Association for the Advancement of Science (AAAS)