Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
説明
<jats:title>Abstract</jats:title><jats:p>The origin of most bacterial infections in the urinary tract is often presumed to be the gut. Herein, we investigate the relationship between the gut microbiota and future development of bacteriuria and urinary tract infection (UTI). We perform gut microbial profiling using 16S rRNA gene deep sequencing on 510 fecal specimens from 168 kidney transplant recipients and metagenomic sequencing on a subset of fecal specimens and urine supernatant specimens. We report that a 1% relative gut abundance of <jats:italic>Escherichia</jats:italic> is an independent risk factor for <jats:italic>Escherichia</jats:italic> bacteriuria and UTI and a 1% relative gut abundance of <jats:italic>Enterococcus</jats:italic> is an independent risk factor for <jats:italic>Enterococcus</jats:italic> bacteriuria. Strain analysis establishes a close strain level alignment between species found in the gut and in the urine in the same subjects. Our results support a gut microbiota–UTI axis, suggesting that modulating the gut microbiota may be a potential novel strategy to prevent UTIs.</jats:p>
収録刊行物
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- Nature Communications
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Nature Communications 10 (1), 5521-, 2019-12-04
Springer Science and Business Media LLC
