Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
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- Lyla A. Youssef
- Department of Microbiology and Immunology,
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- Abdelhadi Rebbaa
- Department of Pathology and Cell Biology,
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- Sergey Pampou
- J. P. Sulzberger Columbia Genome Center,
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- Stuart P. Weisberg
- Department of Pathology and Cell Biology,
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- Brent R. Stockwell
- Department of Biological Sciences, and
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- Eldad A. Hod
- Department of Pathology and Cell Biology,
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- Steven L. Spitalnik
- Department of Pathology and Cell Biology,
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説明
<jats:title>Key Points</jats:title><jats:p>Transfusions of storage-damaged RBCs induce an RPM-dependent inflammatory response by splenic Ly6Chi monocytes. Macrophages undergo ferroptosis following increased erythrophagocytosis and are replaced by circulating monocytes and local cell division.</jats:p>
収録刊行物
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- Blood
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Blood 131 (23), 2581-2593, 2018-06-07
American Society of Hematology