Classification of Uremic Toxins and Their Role in Kidney Failure
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- Mitchell H. Rosner
- Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia
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- Thiago Reis
- Department of Nephrology, University of Brazil, Brasília, Brazil
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- Faeq Husain-Syed
- Department of Internal Medicine II, Justus-Liebig-University Giessen, Giessen, Germany
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- Raymond Vanholder
- Department of Internal Medicine and Pediatrics, University Hospital, Ghent, Belgium
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- Colin Hutchison
- Faculty of Medicine, University of Queensland, Herston, Australia
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- Peter Stenvinkel
- Renal Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Peter J. Blankestijn
- Department of Nephrology and Hypertension, University Medical Centre Utrecht, Utrecht, The Netherlands
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- Mario Cozzolino
- Renal Division, Università degli Studi di Milano, Milan, Italy
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- Laurent Juillard
- University of Lyon, Villeurbanne, France
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- Kianoush Kashani
- Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota
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- Manish Kaushik
- Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore
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- Hideki Kawanishi
- Department of Artificial Organs, Tsuchiya General Hospital, Hiroshima, Japan
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- Ziad Massy
- INSERM U1018, Villejuif, France
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- Tammy Lisa Sirich
- Nephrology Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, California
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- Li Zuo
- Department of Nephrology, Peking University People's Hospital, Beijing, China
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- Claudio Ronco
- Department of Medicine, University of Padova, Padova, Italy
Description
<jats:p>Advances in our understanding of uremic retention solutes, and improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and classification of uremic toxins. A consensus conference was held to develop recommendations for an updated definition and classification scheme on the basis of a holistic approach that incorporates physicochemical characteristics and dialytic removal patterns of uremic retention solutes and their linkage to clinical symptoms and outcomes. The major focus is on the removal of uremic retention solutes by hemodialysis. The identification of representative biomarkers for different classes of uremic retention solutes and their correlation to clinical symptoms and outcomes may facilitate personalized and targeted dialysis prescriptions to improve quality of life, morbidity, and mortality. Recommendations for areas of future research were also formulated, aimed at improving understanding of uremic solutes and improving outcomes in patients with CKD.</jats:p>
Journal
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- Clinical Journal of the American Society of Nephrology
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Clinical Journal of the American Society of Nephrology 16 (12), 1918-1928, 2021-12
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360013170843434752
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- ISSN
- 1555905X
- 15559041
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- Data Source
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- Crossref