Management of Myocarditis-Related Cardiomyopathy in Adults

DOI Web Site 3 Citations
  • Carsten Tschöpe
    From the Charité, University Medicine Berlin, Campus Virchow Klinikum (CVK), Department of Cardiology, Germany (C.T., S.V.L.)
  • Leslie T. Cooper
    Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL (L.T.C.)
  • Guillermo Torre-Amione
    Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (G.T.-A.)
  • Sophie Van Linthout
    From the Charité, University Medicine Berlin, Campus Virchow Klinikum (CVK), Department of Cardiology, Germany (C.T., S.V.L.)

Description

<jats:p>Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.</jats:p>

Journal

  • Circulation Research

    Circulation Research 124 (11), 1568-1583, 2019-05-24

    Ovid Technologies (Wolters Kluwer Health)

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