Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
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- Bing Bai
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Alexandr Belovodskiy
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Mostofa Hena
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Appan Srinivas Kandadai
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Michael A. Joyce
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Holly A. Saffran
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Justin A. Shields
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Muhammad Bashir Khan
- Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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- Elena Arutyunova
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Jimmy Lu
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Sardeev K. Bajwa
- Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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- Darren Hockman
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- Conrad Fischer
- Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
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- Tess Lamer
- Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
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- Wayne Vuong
- Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
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- Marco J. van Belkum
- Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
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- Zhengxian Gu
- WuXi AppTec (Shanghai) Co., Ltd., G Warehouse #101, No. 10 Building, #227 Meisheng Road, WaiGaoQiao Free Trade Zone, Shanghai 200131, China
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- Fusen Lin
- WuXi AppTec (Shanghai) Co., Ltd., G Warehouse #101, No. 10 Building, #227 Meisheng Road, WaiGaoQiao Free Trade Zone, Shanghai 200131, China
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- Yanhua Du
- WuXi AppTec (Shanghai) Co., Ltd., G Warehouse #101, No. 10 Building, #227 Meisheng Road, WaiGaoQiao Free Trade Zone, Shanghai 200131, China
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- Jia Xu
- WuXi AppTec (Shanghai) Co., Ltd., G Warehouse #101, No. 10 Building, #227 Meisheng Road, WaiGaoQiao Free Trade Zone, Shanghai 200131, China
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- Mohammad Rahim
- Rane Pharmaceuticals, Inc. 4290 91a Street NW, Edmonton, Alberta T6E 5V2, Canada
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- Howard S. Young
- Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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- John C. Vederas
- Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
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- D. Lorne Tyrrell
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- M. Joanne Lemieux
- Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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- James A. Nieman
- Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
収録刊行物
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- Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry 65 (4), 2905-2925, 2021-07-09
American Chemical Society (ACS)
