- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Therapeutic strategy for pineal parenchymal tumor of intermediate differentiation (PPTID): case report of PPTID with malignant transformation to pineocytoma with leptomeningeal dissemination 6 years after surgery
-
- Toshiaki Bando
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Yasushi Ueno
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Narihide Shinoda
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Yukihiro Imai
- Department of Pathology, Kobe City Medical Center General Hospital; and
-
- Kazuhito Ichikawa
- Department of Pathology, Shinko Hospital, Kobe, Japan
-
- Yoji Kuramoto
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Takahiro Kuroyama
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Daisuke Shimo
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Kazuyuki Mikami
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Shinya Hori
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Masato Matsumoto
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
-
- Osamu Hirai
- Department of Neurosurgery and Stroke Center, Shinko Hospital;
Search this article
Description
<jats:p>Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal parenchymal tumor (PPT) with an intermediate prognosis between pineocytoma (PC) and pineoblastoma (PB). It is considered an intermediate-grade tumor and divided into WHO grade II or III.</jats:p><jats:p>The number of available reports about PPTID is presently limited, and the appropriate management for this tumor has not yet been determined.</jats:p><jats:p>The authors report a rare case of PC in a 63-year-old woman who presented with lower-extremity weakness and gait disturbance. A pineal mass lesion was detected on MRI. A diagnosis of PC was established after microsurgical gross-total tumor resection, and the patient received no adjuvant therapy after surgery. Two years after surgery, a partial recurrence was recognized and Gamma Knife radiosurgery was performed. Fours years later, the patient developed diffuse leptomeningeal dissemination. She was successfully treated with craniospinal irradiation. Leptomeningeal dissemination may develop 6 years after the initial diagnosis of PC. A histopathological study of the recurrent tumor revealed a malignant change from PC to PPTID.</jats:p><jats:p>The present case shows the importance of long-term follow-up of patients with PPTs following resection and the efficacy of craniospinal irradiation in the treatment of leptomeningeal dissemination.</jats:p>
Journal
-
- Journal of Neurosurgery
-
Journal of Neurosurgery 130 (6), 2009-2015, 2019-06
Journal of Neurosurgery Publishing Group (JNSPG)