Differentially Expressed Genes Extracted by the Tensor Robust Principal Component Analysis (TRPCA) Method

  • Yue Hu
    School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China
  • Jin-Xing Liu
    School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China
  • Ying-Lian Gao
    Library of Qufu Normal University, Qufu Normal University, Rizhao 276826, China
  • Sheng-Jun Li
    School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China
  • Juan Wang
    School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China

抄録

<jats:p>In the big data era, sequencing technology has produced a large number of biological sequencing data. Different views of the cancer genome data provide sufficient complementary information to explore genetic activity. The identification of differentially expressed genes from multiview cancer gene data is of great importance in cancer diagnosis and treatment. In this paper, we propose a novel method for identifying differentially expressed genes based on tensor robust principal component analysis (TRPCA), which extends the matrix method to the processing of multiway data. To identify differentially expressed genes, the plan is carried out as follows. First, multiview data containing cancer gene expression data from different sources are prepared. Second, the original tensor is decomposed into a sum of a low-rank tensor and a sparse tensor using TRPCA. Third, the differentially expressed genes are considered to be sparse perturbed signals and then identified based on the sparse tensor. Fourth, the differentially expressed genes are evaluated using Gene Ontology and Gene Cards tools. The validity of the TRPCA method was tested using two sets of multiview data. The experimental results showed that our method is superior to the representative methods in efficiency and accuracy aspects.</jats:p>

収録刊行物

  • Complexity

    Complexity 2019 1-13, 2019-06-02

    Hindawi Limited

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