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- Charlotte M. Fare
- Department of Biochemistry and Biophysics, and
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- Alexis Villani
- Department of Biochemistry and Biophysics, and
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- Lauren E. Drake
- Department of Biochemistry and Biophysics, and
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- James Shorter
- Department of Biochemistry and Biophysics, and
抄録
<jats:p>A guiding principle of biology is that biochemical reactions must be organized in space and time. One way this spatio-temporal organization is achieved is through liquid–liquid phase separation (LLPS), which generates biomolecular condensates. These condensates are dynamic and reactive, and often contain a complex mixture of proteins and nucleic acids. In this review, we discuss how underlying physical and chemical processes generate internal condensate architectures. We then outline the diverse condensate architectures that are observed in biological systems. Finally, we discuss how specific condensate organization is critical for specific biological functions.</jats:p>
収録刊行物
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- Open Biology
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Open Biology 11 (6), 210137-, 2021-06
The Royal Society