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- Aaron Hardin
- Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA
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- Kimberly A Nevonen
- Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR
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- Walter L Eckalbar
- Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA
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- Lucia Carbone
- Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR
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- Nadav Ahituv
- Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA
抄録
<jats:title>Abstract</jats:title><jats:p>Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands. Here, we generated a genome, variome, and transcriptomes for Mastomys coucha. As mastomys diverged at similar times from mouse and rat, we demonstrate their utility as a comparative genomic tool for these commonly used animal models. Furthermore, we identified over 500 mastomys accelerated regions, often residing near important mammary developmental genes or within their exons leading to protein sequence changes. Functional characterization of a noncoding mastomys accelerated region, located in the HoxD locus, showed enhancer activity in mouse developing mammary glands. Combined, our results provide genomic resources for mastomys and highlight their potential both as a comparative genomic tool and for the identification of mammary gland number determining factors.</jats:p>
収録刊行物
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- Molecular Biology and Evolution
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Molecular Biology and Evolution 36 (12), 2805-2812, 2019-08-20
Oxford University Press (OUP)