Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics
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- Wenjun Wang
- Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China
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- Xiaoqing Liu
- Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China
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- Sipei Wu
- Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong, China
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- Sibei Chen
- Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China
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- Yimin Li
- Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China
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- Lingbo Nong
- Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China
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- Puyi Lie
- Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China
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- Liyan Huang
- Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China
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- Linling Cheng
- Guangzhou Eighth People’s Hospital, Guangdong, China
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- Yongping Lin
- Laboratory Department, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China
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- Jianxing He
- Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China
説明
<jats:title>Abstract</jats:title> <jats:p>Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19.</jats:p>
収録刊行物
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- The Journal of Infectious Diseases
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The Journal of Infectious Diseases 222 (9), 1444-1451, 2020-06-30
Oxford University Press (OUP)