Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)
説明
<jats:title>Abstract</jats:title><jats:p>Key questions in COVID-19 are the duration and determinants of infectious virus shedding. Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19. The median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5–11) and drops below 5% after 15.2 days post onset of symptoms (95% confidence interval (CI) 13.4–17.2). Multivariate analyses identify viral loads above 7 log<jats:sub>10</jats:sub> RNA copies/mL (odds ratio [OR] of 14.7 (CI 3.57-58.1; <jats:italic>p</jats:italic> < 0.001) as independently associated with isolation of infectious SARS-CoV-2 from the respiratory tract. A serum neutralizing antibody titre of at least 1:20 (OR of 0.01 (CI 0.003-0.08; <jats:italic>p</jats:italic> < 0.001) is independently associated with non-infectious SARS-CoV-2. We conclude that quantitative viral RNA load assays and serological assays could be used in test-based strategies to discontinue or de-escalate infection prevention and control precautions.</jats:p>
収録刊行物
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- Nature Communications
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Nature Communications 12 (1), 267-, 2021-01-11
Springer Science and Business Media LLC
