Recurrent evolution of vertebrate transcription factors by transposase capture
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- Rachel L. Cosby
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Julius Judd
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Ruiling Zhang
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Alan Zhong
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Nathaniel Garry
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Ellen J. Pritham
- Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
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- Cédric Feschotte
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
抄録
<jats:title>A recipe for new genes</jats:title> <jats:p> Most lineages contain evolutionarily novel genes, but their origin is not always clear. Cosby <jats:italic>et al.</jats:italic> investigated the origin of families of lineage-specific vertebrate genes (see the Perspective by Wacholder and Carvunis). Fusion between transposable elements (TEs) and host gene exons, once incorporated into the host genome, could generate new functional genes. Examination of <jats:italic>KARABINER</jats:italic> , a bat gene that arose through this process, shows how the retention of part of the TE within this gene allows the transcribed protein to bind throughout the genome and act as a transcriptional regulator. Thus, TEs interacting within their host genome provide the raw material to generate new combinations of functional domains that can be selected upon and incorporated within the hierarchical cellular network. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abc6405">eabc6405</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6531" page="779" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf8493">779</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 371 (6531), eabc6405-, 2021-02-19
American Association for the Advancement of Science (AAAS)