The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397
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- Anna-Maria Dietl
- Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
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- Matthias Misslinger
- Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
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- Mario M. Aguiar
- Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
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- Vasyl Ivashov
- Division Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
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- David Teis
- Division Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
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- Joachim Pfister
- Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria
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- Clemens Decristoforo
- Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria
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- Martin Hermann
- Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria
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- Sean M. Sullivan
- Vical Inc., San Diego, California, USA
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- Larry R. Smith
- Vical Inc., San Diego, California, USA
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- Hubertus Haas
- Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
抄録
<jats:p> VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, renders <jats:named-content content-type="genus-species">Aspergillus fumigatus</jats:named-content> resistant to VL-2397. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 63 (10), 2019-10
American Society for Microbiology