The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397

  • Anna-Maria Dietl
    Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
  • Matthias Misslinger
    Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
  • Mario M. Aguiar
    Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
  • Vasyl Ivashov
    Division Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
  • David Teis
    Division Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
  • Joachim Pfister
    Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria
  • Clemens Decristoforo
    Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria
  • Martin Hermann
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria
  • Sean M. Sullivan
    Vical Inc., San Diego, California, USA
  • Larry R. Smith
    Vical Inc., San Diego, California, USA
  • Hubertus Haas
    Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria

抄録

<jats:p> VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, renders <jats:named-content content-type="genus-species">Aspergillus fumigatus</jats:named-content> resistant to VL-2397. </jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ