Biological Transformation of Blasticidin S by<i>Aspergillus fumigatus</i>sp.

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  • Part I. Isolation, Characterization and Structures of Transformed Products and their Biological Properties

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A strain of Aspergillus fumigatus isolated from soil, transformed blasticidin S into four substances designated U1, U2, U3 and U4 respectively. U1 is less toxic and retains biological activities. Structural elucidation of these compounds comes to the conclusion that they differ from blasticidin S in pyrimidine base, e.g., uracil instead of cytosine nucleus. The structures of U2, U3 and U4 are elucidated.

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