Fourth-Generation QuantiFERON-TB Gold Plus: What Is the Evidence?

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  • Arena Shafeque
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
  • Jacob Bigio
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
  • Catherine A. Hogan
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
  • Madhukar Pai
    McGill International TB Centre, Montreal, Quebec, Canada
  • Niaz Banaei
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
  • Colleen Suzanne Kraft
    editor

Abstract

<jats:p>QuantiFERON-TB Gold Plus (QFT-Plus) is the latest generation of interferon gamma release assays (IGRAs) to receive approval from the U.S. FDA, replacing its predecessor, QuantiFERON-TB Gold In-Tube (QFT-GIT). The novelty of QFT-Plus is that it elicits a response from CD8 T cells, in addition to CD4 T cells, thus collecting a broader response from T-cell subsets than QFT-GIT. It was developed with the aim to improve the detection of latent tuberculosis infection (LTBI), especially among recently exposed contacts, immunocompromised hosts, and young children.</jats:p>

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