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- Trond Lamark
- Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, 9037 Tromsø, Norway;,
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- Terje Johansen
- Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, 9037 Tromsø, Norway;,
説明
<jats:p>Selective autophagy is the lysosomal degradation of specific intracellular components sequestered into autophagosomes, late endosomes, or lysosomes through the activity of selective autophagy receptors (SARs). SARs interact with autophagy-related (ATG)8 family proteins via sequence motifs called LC3-interacting region (LIR) motifs in vertebrates and Atg8-interacting motifs (AIMs) in yeast and plants. SARs can be divided into two broad groups: soluble or membrane bound. Cargo or substrate selection may be independent or dependent of ubiquitin labeling of the cargo. In this review, we discuss mechanisms of mammalian selective autophagy with a focus on the unifying principles employed in substrate recognition, interaction with the forming autophagosome via LIR-ATG8 interactions, and the recruitment of core autophagy components for efficient autophagosome formation on the substrate.</jats:p>
収録刊行物
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- Annual Review of Cell and Developmental Biology
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Annual Review of Cell and Developmental Biology 37 (1), 143-169, 2021-10-06
Annual Reviews