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- Hideto Watanabe
- Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Japan
抄録
<jats:p> Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N- and C-termini. The N-terminal G1 domain binds hyaluronan (HA), forms an HA-rich matrix, and regulates HA-mediated signaling. The C-terminal G3 domain binds other extracellular matrix molecules and forms a supramolecular structure that stores transforming growth factor β (TGFβ) and bone morphogenetic proteins (BMPs) and regulates their signaling. EGF-like motifs in the G3 domain may directly act like an EGF ligand. Both Acan and Vcan are present in cartilage, intervertebral disc, brain, heart, and aorta. Their localizations are essentially reciprocal. This review describes their structural domains, expression patterns and functions, and regulation of their expression. </jats:p>
収録刊行物
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- American Journal of Physiology-Cell Physiology
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American Journal of Physiology-Cell Physiology 322 (5), C967-C976, 2022-05-01
American Physiological Society
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360013246107057408
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- ISSN
- 15221563
- 03636143
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- データソース種別
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- Crossref
- KAKEN