Mouse models of sarcopenia: classification and evaluation

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  • Wen‐qing Xie
    Department of Orthopedics, Xiangya Hospital Central South University Changsha Hunan China
  • Miao He
    Department of Orthopedics, Xiangya Hospital Central South University Changsha Hunan China
  • Deng‐jie Yu
    Department of Orthopedics, Xiangya Hospital Central South University Changsha Hunan China
  • Yu‐xiang Wu
    School of Kinesiology Jianghan University Wuhan Hubei China
  • Xiu‐hua Wang
    Xiang Ya Nursing School The Central South University Changsha Hunan China
  • Shan Lv
    Department of Geriatric Endocrinology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China
  • Wen‐feng Xiao
    Department of Orthopedics, Xiangya Hospital Central South University Changsha Hunan China
  • Yu‐sheng Li
    Department of Orthopedics, Xiangya Hospital Central South University Changsha Hunan China

抄録

<jats:title>Abstract</jats:title><jats:p>Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an increased possibility of adverse consequences such as falls, fractures, physical disabilities and death, and its risk increases with age. With the deepening of the understanding of sarcopenia, the disease has become a major clinical disease of the elderly and a key challenge of healthy ageing. However, the exact molecular mechanism of this disease is still unclear, and the selection of treatment strategies and the evaluation of its effect are not the same. Most importantly, the early symptoms of this disease are not obvious and are easy to ignore. In addition, the clinical manifestations of each patient are not exactly the same, which makes it difficult to effectively study the progression of sarcopenia. Therefore, it is necessary to develop and use animal models to understand the pathophysiology of sarcopenia and develop therapeutic strategies. This paper reviews the mouse models that can be used in the study of sarcopenia, including ageing models, genetically engineered models, hindlimb suspension models, chemical induction models, denervation models, and immobilization models; analyses their advantages and disadvantages and application scope; and finally summarizes the evaluation of sarcopenia in mouse models.</jats:p>

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