Site-Selective Spin-Probe with a Photocleavable Macrocyclic Linker for Measuring the Dynamics of Water Surrounding a Liposomal Assembly

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  • Gyeorye Lee
    Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita-10 Nishi-8, Kita-ku, Sapporo, Hokkaido 060-0810 , Japan
  • Yoshiyuki Kageyama
    Faculty of Science, Hokkaido University, Kita-10 Nishi-8, Kita-ku, Sapporo, Hokkaido 060-0810 , Japan
  • Sadamu Takeda
    Faculty of Science, Hokkaido University, Kita-10 Nishi-8, Kita-ku, Sapporo, Hokkaido 060-0810 , Japan

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<jats:title>Abstract</jats:title> <jats:p>There is a growing interest in the behavior of water on the hydration layer of a soft matter surface in order to develop wet materials that can function in an aqueous environment and to increase the understanding of complex biological phenomena. Dynamic nuclear polarization (DNP), which increases the sensitivity of nuclear magnetic resonance (NMR) by enhancing the magnetization of nuclear spin with the magnetization of electron spin, has recently attracted attention as a method to measure the dynamics of water of hydration. The design of functional spin probes is expected to provide on-demand measurements. In this study, we report the results of an in-situ, site-selective measurement method of water surrounding liposomes using a photolyzable macrocycle. We succeeded in measuring the difference in water dynamics at two different regions around the liposomal membrane of the same sample by the photocleavage of an o-nitrobenzyl ether derivative.</jats:p>

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